Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors

@article{Kawashima2006Rac1AA,
  title={Rac1 and a GTPase-activating protein, MgcRacGAP, are required for nuclear translocation of STAT transcription factors},
  author={Toshiyuki Kawashima and Ying Chun Bao and Yasushi Nomura and Yuseok Moon and Yukio Tonozuka and Yukinori Minoshima and Tomonori Hatori and Akiho Tsuchiya and Mari Kiyono and Tetsuya Nosaka and Hideaki Nakajima and David A Williams and Toshio Kitamura},
  journal={The Journal of Cell Biology},
  year={2006},
  volume={175},
  pages={937 - 946}
}
STAT transcription factors are tyrosine phosphorylated upon cytokine stimulation and enter the nucleus to activate target genes. We show that Rac1 and a GTPase-activating protein, MgcRacGAP, bind directly to p-STAT5A and are required to promote its nuclear translocation. Using permeabilized cells, we find that nuclear translocation of purified p-STAT5A is dependent on the addition of GTP-bound Rac1, MgcRacGAP, importin alpha, and importin beta. p-STAT3 also enters the nucleus via this transport… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 50 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

STAT5 induces macro

  • T. Kawashima, K. Murata, +7 authors S. Asano
  • 2001
Highly Influential
3 Excerpts

Similar Papers

Loading similar papers…