Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.

@article{Nethe2012Rac1AI,
  title={Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts.},
  author={Micha Nethe and Bart-Jan de Kreuk and Daniele V F Tauriello and Eloise C. Anthony and Barbara C. Snoek and Thomas Stumpel and Patricia C. Salinas and Madelon M Maurice and Dirk Geerts and Andr{\'e} M. Deelder and Paul J Hensbergen and Peter L Hordijk},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 14},
  pages={3430-42}
}
The Rho-GTPase Rac1 promotes actin polymerization and membrane protrusion that mediate initial contact and subsequent maturation of cell-cell junctions. Here we report that Rac1 associates with the ubiquitin-protein ligase neural precursor cell expressed developmentally down-regulated 4 (Nedd4). This interaction requires the hypervariable C-terminal domain of Rac1 and the WW domains of Nedd4. Activated Rac1 colocalises with endogenous Nedd4 at epithelial cell-cell contacts. Reduction of Nedd4… CONTINUE READING
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The C-terminal domain of Rac1 contains two motifs that control targeting and signaling specificity

  • P. B. van Hennik, J. P. ten Klooster, +4 authors P. L. Hordijk
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