Rac1 Regulates Interleukin 1-induced Nuclear Factor kB Activation in an Inhibitory Protein kBa-independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression*

Abstract

We have examined the involvement of Rac1 in nuclear factor kB (NFkB) activation by interleukin 1 (IL1). IL1 induced a rapid and sustained activation of Rac1 in the thymoma cell line EL4.NOB-1. Transient transfection with dominant negative RacN17 inhibited IL1-induced kB-dependent reporter gene expression but not IkBa degradation, whereas constitutively… (More)

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@inproceedings{Jefferies2000Rac1RI, title={Rac1 Regulates Interleukin 1-induced Nuclear Factor kB Activation in an Inhibitory Protein kBa-independent Manner by Enhancing the Ability of the p65 Subunit to Transactivate Gene Expression*}, author={Caroline A. Jefferies and Luke A. J. O’Neill}, year={2000} }