Rac1 GTPase acts downstream of αPS1βPS integrin to control collective migration and lumen size in the Drosophila salivary gland.

@article{Pirraglia2013Rac1GA,
  title={Rac1 GTPase acts downstream of αPS1βPS integrin to control collective migration and lumen size in the Drosophila salivary gland.},
  author={Carolyn Pirraglia and Jenna M. Walters and Nancy Ahn and Monn Monn Myat},
  journal={Developmental biology},
  year={2013},
  volume={377 1},
  pages={
          21-32
        }
}
During collective migration of the Drosophila embryonic salivary gland, the distal gland cells mediate integrin-based contacts with surrounding tissues while proximal gland cells change shape and rearrange. Here, we show that αPS1βPS integrin controls salivary gland migration through Rac1 GTPase which downregulates E-cadherin in proximal and distal gland cells, and promotes extension of actin-rich basal membrane protrusions in the distal cells. In embryos mutant for multiple edematous wings… CONTINUE READING
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