Rac signaling in tumorigenesis and as target for anticancer drug development.

@article{Sun2006RacSI,
  title={Rac signaling in tumorigenesis and as target for anticancer drug development.},
  author={Di Sun and Duo Xu and Baolin Zhang},
  journal={Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy},
  year={2006},
  volume={9 6},
  pages={274-87}
}
Rac GTPases are crucial signaling regulators in eukaryotic cells, acting downstream of many cell surface receptors. They play essential roles in diverse cellular functions including cytoskeleton dynamics, cell motility, cell survival and apoptosis. Their activities are controlled by a tightly regulated GDP/GTP cycle coupled with an alternation between cytoplasm and membrane compartments. Aberrant Rac signaling is found in some human cancers as a result of changes in the GTPase itself or in its… CONTINUE READING