Rac regulates vascular endothelial growth factor stimulated motility.

  title={Rac regulates vascular endothelial growth factor stimulated motility.},
  author={Norihito Soga and John O. Connolly and Meenakshi A Chellaiah and Juichi Kawamura and Keith A. Hruska},
  journal={Cell communication & adhesion},
  volume={8 1},
During angiogenesis endothelial cells migrate towards a chemotactic stimulus. Understanding the mechanism of endothelial cell migration is critical to the therapeutic manipulation of angiogenesis and ultimately cancer prevention. Vascular endothelial growth factor (VEGF) is a potent chemotactic stimulus of endothelial cells during angiogenesis. The endothelial cell signal transduction pathway of VEGF represents a potential target for cancer therapy, but the mechanisms of post-receptor signal… CONTINUE READING
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