Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration

@article{Kiosses2001RacRH,
  title={Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration},
  author={William B. Kiosses and Sanford J Shattil and Nisar Pampori and Martin A Schwartz},
  journal={Nature Cell Biology},
  year={2001},
  volume={3},
  pages={316-320}
}
Integrin αvβ3 has an important role in the proliferation, survival, invasion and migration of vascular endothelial cells. Like other integrins, αvβ3 can exist in different functional states with respect to ligand binding. These changes involve both affinity modulation, by which conformational changes in the integrin heterodimer govern affinity for individual extracellular matrix proteins, and avidity modulation, by which changes in lateral mobility and integrin clustering affect the binding of… CONTINUE READING