Rac is involved in early TCR signaling.

  title={Rac is involved in early TCR signaling.},
  author={C{\'e}cile Arrieumerlou and Clotilde Randriamampita and Georges Bismuth and Alain Trautmann},
  journal={Journal of immunology},
  volume={165 6},
The GTPase Rac controls signaling pathways often related to actin polymerization in various cell types. In T lymphocytes, Rac is activated by Vav, a major component of the multiprotein transduction complex associated to the TCR. Although profound signaling defects have been observed in Vav-deficient mice, a role of Rac in the corresponding early TCR signaling has not been tested directly. This question was investigated in Jurkat T cells transfected with either a dominant-negative (RacN17) or a… CONTINUE READING