Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion.

@article{Carabeo2007RacIW,
  title={Rac interacts with Abi-1 and WAVE2 to promote an Arp2/3-dependent actin recruitment during chlamydial invasion.},
  author={Rey A Carabeo and Cheryl A. Dooley and Scott S. Grieshaber and Ted Hackstadt},
  journal={Cellular microbiology},
  year={2007},
  volume={9 9},
  pages={
          2278-88
        }
}
Chlamydiae are Gram-negative obligate intracellular pathogens to which access to an intracellular environment is fundamental to their development. Chlamydial attachment to host cells induces the activation of the Rac GTPase, which is required for the localization of WAVE2 at the sites of chlamydial entry. Co-immunoprecipitation experiments demonstrated that Chlamydia trachomatis infection promoted the interaction of Rac with WAVE2 and Abi-1, but not with IRSp53. siRNA depletion of WAVE2 and Abi… CONTINUE READING

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