Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells.

@article{WjciakStothard2005RacAR,
  title={Rac and Rho play opposing roles in the regulation of hypoxia/reoxygenation-induced permeability changes in pulmonary artery endothelial cells.},
  author={Beata W{\'o}jciak-Stothard and Lillian Yen Fen Tsang and Sheila. G. Haworth},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={2005},
  volume={288 4},
  pages={
          L749-60
        }
}
Hypoxia/reoxygenation-induced changes in endothelial permeability are accompanied by endothelial actin cytoskeletal and adherens junction remodeling, but the mechanisms involved are uncertain. We therefore measured the activities of the Rho GTPases Rac1, RhoA, and Cdc42 during hypoxia/reoxygenation and correlated them with changes in endothelial permeability, remodeling of the actin cytoskeleton and adherens junctions, and production of ROS. Dominant negative forms of Rho GTPases were… CONTINUE READING
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