Rac and Rho Mediate Opposing Hormonal Regulation of the Ether-A-Go-Go-Related Potassium Channel

@article{Storey2002RacAR,
  title={Rac and Rho Mediate Opposing Hormonal Regulation of the Ether-A-Go-Go-Related Potassium Channel},
  author={Nina M. Storey and John P. O’Bryan and David Lee Armstrong},
  journal={Current Biology},
  year={2002},
  volume={12},
  pages={27-33}
}
BACKGROUND Previous studies of ion channel regulation by G proteins have focused on the larger, heterotrimeric GTPases, which are activated by heptahelical membrane receptors. In contrast, studies of the Rho family of smaller, monomeric, Ras-related GTPases, which are activated by cytoplasmic guanine nucleotide exchange factors, have focused on their role in cytoskeletal regulation. RESULTS Here we demonstrate novel functions for the Rho family GTPases Rac and Rho in the opposing hormonal… Expand
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