Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization.

@article{Yang2001RacAC,
  title={Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization.},
  author={Fengchun Yang and Simon J. Atkinson and Yusu Gu and Jovencio Borneo and Andrew W Roberts and Yi cheng Zheng and Janice Pennington and David A Williams},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 10},
  pages={5614-8}
}
Critical to homeostasis of blood cell production by hematopoietic stem/progenitor (HSC/P) cells is the regulation of HSC/P retention within the bone marrow microenvironment and migration between the bone marrow and the blood. Key extracellular regulatory elements for this process have been defined (cell-cell adhesion, growth factors, chemokines), but the mechanism by which HSC/P cells reconcile multiple external signals has not been elucidated. Rac and related small GTPases are candidates for… CONTINUE READING

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