Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion.

@article{Yamazaki2007RacWAVEmediatedAR,
  title={Rac-WAVE-mediated actin reorganization is required for organization and maintenance of cell-cell adhesion.},
  author={D. Yamazaki and Tsukasa Oikawa and Tadaomi Takenawa},
  journal={Journal of cell science},
  year={2007},
  volume={120 Pt 1},
  pages={86-100}
}
During cadherin-dependent cell-cell adhesion, the actin cytoskeleton undergoes dynamic reorganization in epithelial cells. Rho-family small GTPases, which regulate actin dynamics, play pivotal roles in cadherin-dependent cell-cell adhesion; however, the precise molecular mechanisms that underlie cell-cell adhesion formation remain unclear. Here we show that Wiskott-Aldrich syndrome protein family verprolin-homologous protein (WAVE)-mediated reorganization of actin, downstream of Rac plays an… CONTINUE READING

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