Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock

Abstract

Sensing the osmolarity of the environment is a critical response for all organisms. Whereas bacteria will migrate away from high osmotic conditions, most eukaryotic cells are not motile and use adaptive metabolic responses for survival. The p38 MAPK pathway is a crucial mediator of survival during cellular stress. We have discovered a novel scaffold protein… (More)
DOI: 10.1038/ncb1071

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Cite this paper

@article{Uhlik2003RacMEKK3MKK3SF, title={Rac–MEKK3–MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock}, author={Mark T. Uhlik and Amy N. Abell and Nancy Lassignal Johnson and Weiyong Sun and Bruce D. Cuevas and Katherine E. Lobel-Rice and Eric A. Horne and Mark L Dell'Acqua and Gary Leon Johnson}, journal={Nature Cell Biology}, year={2003}, volume={5}, pages={1104-1110} }