Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.

@article{Kalfa2006RacGR,
  title={Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton.},
  author={Theodosia A Kalfa and Suvarnamala Pushkaran and Narla Mohandas and John H. Hartwig and Velia M Fowler and James Ford Johnson and Clinton H. Joiner and David A Williams and Yi cheng Zheng},
  journal={Blood},
  year={2006},
  volume={108 12},
  pages={3637-45}
}
Actin oligomers are a significant structural component of the erythrocyte cytoskeleton. Rac1 and Rac2 GTPases regulate actin structures and have multiple overlapping as well as distinct roles in hematopoietic cells; therefore, we studied their role in red blood cells (RBCs). Conditional gene targeting with a loxP-flanked Rac1 gene allowed Crerecombinase… CONTINUE READING