Rac GTPase plays an essential role in exocytosis by controlling the fusion competence of release sites.

@article{Humeau2002RacGP,
  title={Rac GTPase plays an essential role in exocytosis by controlling the fusion competence of release sites.},
  author={Yann Humeau and Michel Robert Popoff and Hiroshi Kojima and Fr{\'e}d{\'e}ric Doussau and Bernard Poulain},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2002},
  volume={22 18},
  pages={7968-81}
}
The role of small GTPases of the Rho family in synaptic functions has been addressed by analyzing the effects of lethal toxin (LT) from Clostridium sordellii strain IP82 (LT82) on neurotransmitter release at evoked identified synapses in the buccal ganglion of Aplysia. LT82 is a large monoglucosyltranferase that uses UDP-glucose as cofactor and glucosylates Rac (a small GTPase related to Rho), and Ras, Ral, and Rap (three GTPases of the Ras family). Intraneuronal application of LT (50 nm… CONTINUE READING
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