Rabies virus-based vaccines elicit neutralizing antibodies, poly-functional CD8+ T cell, and protect rhesus macaques from AIDS-like disease after SIV(mac251) challenge.

@article{Faul2009RabiesVV,
  title={Rabies virus-based vaccines elicit neutralizing antibodies, poly-functional CD8+ T cell, and protect rhesus macaques from AIDS-like disease after SIV(mac251) challenge.},
  author={Elizabeth J. Faul and Pyone P Aye and Amy B. Papaneri and Bapi Pahar and James P. McGettigan and Faith R. Schiro and Inna Chervoneva and David C. Montefiori and Andrew A Lackner and Matthias J Schnell},
  journal={Vaccine},
  year={2009},
  volume={28 2},
  pages={299-308}
}
Highly attenuated rabies virus (RV) vaccine vectors were evaluated for their ability to protect against highly pathogenic SIV(mac251) challenge. Mamu-A*01 negative rhesus macaques were immunized in groups of four with either: RV expressing SIV(mac239)-GagPol, a combination of RV expressing SIV(mac239)-Env and RV expressing SIV(mac239)-GagPol, or with empty RV vectors. Eight weeks later animals received a booster immunization with a heterologous RV expressing the same antigens. At 12 weeks post… CONTINUE READING