Rabies Virus Infection Induces Type I Interferon Production in an IPS-1 Dependent Manner While Dendritic Cell Activation Relies on IFNAR Signaling

@inproceedings{Faul2010RabiesVI,
  title={Rabies Virus Infection Induces Type I Interferon Production in an IPS-1 Dependent Manner While Dendritic Cell Activation Relies on IFNAR Signaling},
  author={Elizabeth J. Faul and Celestine N. Wanjalla and Mehul S Suthar and Michael Gale and Christoph Wirblich and Matthias J Schnell},
  booktitle={PLoS pathogens},
  year={2010}
}
As with many viruses, rabies virus (RABV) infection induces type I interferon (IFN) production within the infected host cells. However, RABV has evolved mechanisms by which to inhibit IFN production in order to sustain infection. Here we show that RABV infection of dendritic cells (DC) induces potent type I IFN production and DC activation. Although DCs are infected by RABV, the viral replication is highly suppressed in DCs, rendering the infection non-productive. We exploited this finding in… CONTINUE READING

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