Rabies: still a uniformly fatal disease? Historical occurrence, epidemiological trends, and paradigm shifts.


Rabies has the highest case fatality of any infectious disease. Pathobiological and clinical insights have questioned the assertion that death is inevitable after onset of acute encephalomyelitis. Relying upon national laboratory-based surveillance, we reviewed records of human rabies acquired in the United States during 1960-2009. Changes in the… (More)
DOI: 10.1007/s11908-012-0268-2