Rabbit monoarticular arthritis as a model for intra-articular drug injections. The local action of administered cortisol and alpha-1 proteinase inhibitor

@article{Pitt1984RabbitMA,
  title={Rabbit monoarticular arthritis as a model for intra-articular drug injections. The local action of administered cortisol and alpha-1 proteinase inhibitor},
  author={Eva Pitt and David A Lewis},
  journal={Agents and Actions},
  year={1984},
  volume={15},
  pages={541-548}
}
Monoarticular arthritis in the rabbit has been used to study the effect of intra-articular administration of cortisol-21-phosphate and alpha-1-proteinase inhibitor. The preparations were administered both separately and in combination. All treatments improved parameters associated with joint biochemistry and histopathology, but the greatest effect was found when steroid was combined with antiproteinase. Cortisol-21-phosphate had both an anti-inflammatory and anti-arthritic action, whereas alpha… CONTINUE READING