Rabbit hemorrhagic viral disease: characterization of a new animal model of fulminant liver failure.

@article{Tun2003RabbitHV,
  title={Rabbit hemorrhagic viral disease: characterization of a new animal model of fulminant liver failure.},
  author={Mar{\'i}a Jes{\'u}s Tu{\~n}{\'o}n and Sonia S{\'a}nchez-Campos and Javier Garcia-Ferreras and Marcelino L{\'o}pez {\'A}lvarez and Francisco Jorquera and Javier Gonz{\'a}lez-Gallego},
  journal={The Journal of laboratory and clinical medicine},
  year={2003},
  volume={141 4},
  pages={272-8}
}
In this study we sought to characterize a novel model of fulminant liver failure (FLF) by means of experimental infection of rabbits with the rabbit hemorrhagic disease virus (RHDV). Thirty-seven 9-week-old rabbits were injected intramuscularly with 2 x 10(4) hemagglutination units of an RHDV isolate. Eighty-five percent of rabbits died 36 to 54 hours after infection. From 36 hours after infection we noted marked increases in transaminases, lactate dehydrogenase, and total bilirubin. The… CONTINUE READING

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