Rabbit esophageal cells show regulatory volume decrease: ionic basis and effect of pH.

@article{Snow1993RabbitEC,
  title={Rabbit esophageal cells show regulatory volume decrease: ionic basis and effect of pH.},
  author={J C Snow and Jay L. Goldstein and L N Schmidt and P Lisitza and Thomas J. Layden},
  journal={Gastroenterology},
  year={1993},
  volume={105 1},
  pages={102-10}
}
BACKGROUND Regulatory volume decrease (RVD) after osmotic cellular swelling has been shown in several gastrointestinal epithelia but not in esophageal cells. In acid reflux disease, esophageal injury may be related in part to loss of RVD. METHODS Isolated basal esophageal cells were exposed to an external hyposmolar solution, and changes in relative cell size were assessed using a Coulter counter (Hilaleah, FL) in the presence of K+ and Cl- transport inhibitors and at varying extracellular pH… CONTINUE READING

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