Rabbit conjunctival epithelium transports fluid, and P2Y2(2) receptor agonists stimulate Cl(-) and fluid secretion.

@article{Li2001RabbitCE,
  title={Rabbit conjunctival epithelium transports fluid, and P2Y2(2) receptor agonists stimulate Cl(-) and fluid secretion.},
  author={Yongmei Li and Kunyan Kuang and Benjamin R. Yerxa and Q Wen and Heinz Rosskothen and Jorge Fischbarg},
  journal={American journal of physiology. Cell physiology},
  year={2001},
  volume={281 2},
  pages={C595-602}
}
Rabbit conjunctival epithelium exhibits UTP-dependent Cl(-) secretion into the tears. We investigated whether fluid secretion also takes place. Short-circuit current (I(sc)) was 14.9 +/- 1.4 microA/cm(2) (n = 16). Four P2Y(2) purinergic receptor agonists [UTP and the novel compounds INS365, INS306, and INS440 (Inspire Pharmaceuticals)] added apically (10 microM) resulted in temporary (approximately 30 min) I(sc) increases (88%, 66%, 57%, and 28%, respectively; n = 4 each). Importantly, the… CONTINUE READING

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