Rabbit aortic histamine synthesis following short-term cholesterol feeding.

@article{Hollis1975RabbitAH,
  title={Rabbit aortic histamine synthesis following short-term cholesterol feeding.},
  author={T. M. Hollis and R. J. Sloss},
  journal={Atherosclerosis},
  year={1975},
  volume={21 2},
  pages={
          125-34
        }
}
The histidine decarboxylase (HD) activity of thoracic and abdominal aortic segments obtained from male, Dutch-belted rabbits fed a diet containing 0.5 per cent cholesterol for periods of either 2 or 4 weeks was examined. Mean thoracic aortic HD activities, expressed as histamine-forming capacity (HFC), were 3911 plus or minus 492, 6254 plus or minus 656, and 6215 plus or minus 878 dpm/100 mg benzenesulfonylhistamine (BSH) for the control group and from rabbits fed cholesterol for 2 and 4 weeks… 
12 Citations
Rabbit aortic endothelial and medial histamine synthesis following short-term cholesterol feeding.
TLDR
Results indicate that an atherogenic stress promotes increased endothelial histamine synthesis in pair-fed male Dutch belted rabbits, and indicate the experimental rabbits were in a hypercholesteremic, preatherosclerotic state.
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Findings indicate that the aortic HD system may be an important enzymatic coupler involved in vascular permeability alterations occurring early in the atherogenic sequence.
Aortic Endothelial and Smooth Muscle Histamine Metabolism in Experimental Diabetes
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The results support the concept that a large vessel response similar to the microclrculatory prolonged phase of inflammation occurs In experimental diabetes, and suggest that Insulin administration under conditions of experlmentai diabetes may modulate aortic histamine metabolism and the resultant Intraaortlc histamine pools.
Local Aortic Histamine Metabolism and Albumin Accumulation
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It is indicated that blue areas, believed to represent areas of spontaneous hemodynamic-induced vascular injury, have a larger nascent histamine pool than do contiguous white areas and that the distribution of histamine and histamine synthesis in the aorta is highly variable depending on the region examined.
Astemizole reduces blood-retinal barrier leakage in experimental diabetes.
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Data indicate that astemizole, an H1-receptor antagonist that does not cross the blood-retinal barrier, is effective in reversing blood- retinal barrier leakage of albumin in experimental diabetes.
Detection of histidine decarboxylase mRNA in human vascular smooth muscle and endothelial cells.
  • A. Tippens, C. A. Gruetter
  • Biology, Medicine
    Inflammation research : official journal of the European Histamine Research Society ... [et al.]
  • 2004
TLDR
These findings are the first to indicate the presence of HDC mRNA in vascular smooth muscle cells and confirm the presence in endothelial cells which is consistent with an ability of these cell types to synthesize histamine in the vascular wall.
The lipid-lowering profile in rodents. AZ-1355, a new dibenzoxazepine derivative.
The lipid-lowering profile of ethyl 10,11-dihydro-4-methoxydibenz[b,f]-(1,4)oxazepine-8-carboxylate (AZ-1355) has been evaluated using clofibrate as a reference compound. This compound is
Density-dependent contraction of the endothelial nascent histamine pool by exogenous heparin.
TLDR
It is proposed that the metabolic effects of exogenous heparin, and perhaps endogenous heparins, extend to specific modulations of the BAEC nascent histamine pool.
Role of hypertension in atherosclerosis and cardiovascular disease.
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The patient with hypertension is a candidate for both hypertensive and atherosclerotic vascular disease of the coronary and cerebral vessels leading to occlusive disease of both the large and small arteries and resulting in myocardial infarction and stroke.
Lipid metabolism: the histamine-glycosaminoglycan-histaminase connection.
TLDR
A reappraisal of the situation in the light of recent observations has led to believe that lipid absorption and redistribution is under the control of a histamine-glycosaminoglycan-histaminase system which regulates vascular permeability.
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