Rabbit aorta glutathione S-transferases and their role in bioactivation of trinitroglycerin.

@article{Singhal1996RabbitAG,
  title={Rabbit aorta glutathione S-transferases and their role in bioactivation of trinitroglycerin.},
  author={Sharad S Singhal and John Piper and Sanjay Kumar Srivastava and M. Chaubey and Joanna Bandorowicz-Pikula and Sanjay Awasthi and Yogesh C. Awasthi},
  journal={Toxicology and applied pharmacology},
  year={1996},
  volume={140 2},
  pages={378-86}
}
The pharmacological action of glyceryl trinitrate (GTN), a widely used drug for the treatment of angina pectoris, is thought to be mediated through release of nitric oxide (NO) during its biotransformation. Since glutathione S-transferases (GST) can utilize GTN as substrate and GST inhibitors can attenuate GTN-induced relaxation of rabbit aorta in vitro it has been suggested that these enzymes are involved in the bioactivation of GTN in rabbit aorta. Because GSTs are multifunctional enzymes and… CONTINUE READING

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The pharmacological action of glyceryl trinitrate ( GTN ) , a widely used drug for the treatment of angina pectoris , is thought to be mediated through release of nitric oxide ( NO ) during its biotransformation .
The pharmacological action of glyceryl trinitrate ( GTN ) , a widely used drug for the treatment of angina pectoris , is thought to be mediated through release of nitric oxide ( NO ) during its biotransformation .
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