Rabbit antithymocyte globulin related decrease in platelet count reduced risk of pediatric renal transplant graft thrombosis

@article{Kamel2006RabbitAG,
  title={Rabbit antithymocyte globulin related decrease in platelet count reduced risk of pediatric renal transplant graft thrombosis},
  author={Mohamed H. Kamel and Ponnusamy Mohan and P. J. Conlon and Dilly M. Little and Patrick O'kelly and David P. Hickey},
  journal={Pediatric Transplantation},
  year={2006},
  volume={10}
}
Abstract:  Graft thrombosis is a serious complication in pediatric renal transplantation. We assess a potential protective effect for the decrease in platelet count associated with RATG therapy against pediatric renal transplant graft vascular thrombosis. Between January 1986 and December 1998, 120 kidney transplants were performed in 95 pediatric recipients. Patients were divided into two groups. Group 1 (n = 61), non‐RATG group received cyclosporine, azathioprine and steroids, while group 2… 
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Pediatric kidney transplantation: a review
TLDR
This review focuses on the current practices and outcomes in pediatric kidney transplantation in North America and discusses the indications for transplantation, the evaluation process, some key surgical and immunologic considerations, and the common risk factors for graft dysfunction.
Renal allograft loss due to renal vascular thrombosis in the US pediatric renal transplantation
TLDR
The incidence of allograft loss due to RVT significantly and continuously declined among pediatric kidney transplants performed between 1995 and 2014 and the causes for this improvement are unclear in the present analysis.
Renal allograft thrombosis.
  • C. Ponticelli, M. Moia, G. Montagnino
  • Medicine
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2009
TLDR
Paediatric transplant recipients of kidneys from cadaver donors <5 years of age had a significantly higher thrombosis rate than did recipients from older donors, which is attributable to the discrepancy in the size between the vessels of the donor and the recipient.
Identification of Risk Factors for Vascular Thrombosis May Reduce Early Renal Graft Loss: A Review of Recent Literature
TLDR
Thrombosis cannot be entirely prevented and means to an early detection of this complication is desirable in order to save the kidneys through prompt reoperation, and microdialysis may be a new tool for this.
Reply to Hamidian Jahromi and Bastani: Acute early transplant renal artery thrombosis; a complex etiologic diagnosis
TLDR
This article discusses renal artery thrombosis as a complication of distal renal artery stenosis in a kidney transplant recipient as well as a differential diagnosis of acute kidney injury occurring immediately post-kidney transplantation.
Pediatric transplantation: preventing thrombosis
  • J. Robertson
  • Medicine, Biology
    Journal of thrombosis and haemostasis : JTH
  • 2015
TLDR
This review summarizes the available evidence and rationale underlying the spectrum of current practices aimed at preventing thrombosis in the transplant recipient, with a particular focus on risk factors, pathophysiology, and described antithrombotic regimens.
Late Onset Renal Vein Thrombosis after Kidney Transplantation
TLDR
A 32-year-old man underwent deceased kidney transplantation 2 years prior and suddenly developed Oliguria and pain at the allograft site along with an elevated serum creatinine level, and renal vein thrombosis disappeared after 3 months of treatment.
Long‐term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation
TLDR
The long‐term outcome of intensive initial immunosuppression protocol in pediatric deceased donor renal transplantation and the need for further studies are still unclear.
Vascular Complications in Renal Transplantation
Early outcome in renal transplantation from large donors to small and size‐matched recipients – A porcine experimental model
TLDR
Early outcome in renal transplantation from large donors to small and size‐matched recipients – A porcine experimental model.
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References

SHOWING 1-10 OF 22 REFERENCES
Induction of thromboses within renal grafts by high-dose prophylactic OKT3
Low dose aspirin as prophylaxis against renal-vein thrombosis in renal-transplant recipients.
TLDR
A significant reduction in the incidence of RVT is indicated with the addition of low-dose aspirin in cadaveric and living-related renal transplant recipients receiving cyclosporin-based triple immunosuppression.
Pretransplant peritoneal dialysis and graft thrombosis following pediatric kidney transplantation: A NAPRTCS report
TLDR
It is concluded that pretransplant PD is associated with an increased risk of graft thrombosis in pediatric renal transplant patients who have received PD, especially infants and young children.
Assessment of the coagulation profile in hemato-oncological patients receiving ATG-based conditioning treatment for allogeneic stem cell transplantation
TLDR
The results suggest that allo-SCT is not associated with increased hyper coagulability and addition of ATG to conditioning regimen has no significant procoagulant effect.
Advantage of antithymocyte globulin induction in sensitized kidney recipients: a randomized prospective study comparing induction with and without antithymocyte globulin.
TLDR
It is concluded that ATG induction is beneficial for all sensitized patients, regardless of their level of sensitization, with regard to acute rejection episodes, graft survival and graft function.
Increased incidence of lymphoproliferative disorder after immunosuppression with the monoclonal antibody OKT3 in cardiac-transplant recipients.
TLDR
The addition of OKT3 to the immunosuppressive regimen increases the incidence of post-transplantation lymphoproliferative disorder after cardiac transplantation, and the risk increases sharply after cumulative doses greater than 75 mg.
Risk for post‐transplant lymphoproliferative disorder after polyclonal antibody induction in kidney transplantation
Abstract:  The adjusted relative risk (aRR) for development of post‐transplant lymphoproliferative disorder (PTLD) is higher in kidney transplant recipients receiving monoclonal antibody induction…
Renal transplantation in children with congenital nephrotic syndrome: a report of the North American Pediatric Renal Transplant Cooperative Study (NAPRTCS).
TLDR
There is a high rate of renal graft failure in pediatric patients with Congenital Nephrotic Syndrome and care should be taken to eliminate risk factors for hypercoagulability and infections prior to transplantation in children with CNS.
Primary vascular thrombosis after renal transplantation in children.
TLDR
It is concluded that acute tubular necrosis, rejection and unstable volemia may predispose to vascular thrombosis and in selected cases, early diagnosis of vascular thROMbosis may enable graft salvage by surgical or thrombolytic treatment.
Risk factors for vascular thrombosis in pediatric renal transplantation: a special report of the North American Pediatric Renal Transplant Cooperative Study.
TLDR
For both LD and CAD organ recipients, the occurrence of acute tubular necrosis was a significnat risk factor for the development of thrombosis, and the use of antibody induction therapy, donors greater than 5 years of age, and increasing recipient age were factors that decreased the risk for thromBosis.
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