Rab8a regulates the exocyst-mediated kiss-and-run discharge of the Dictyostelium contractile vacuole

@inproceedings{Essid2012Rab8aRT,
  title={Rab8a regulates the exocyst-mediated kiss-and-run discharge of the Dictyostelium contractile vacuole},
  author={Miriam Essid and Navin Gopaldass and Kunito Yoshida and Christien J. Merrifield and Thierry Soldati},
  booktitle={Molecular biology of the cell},
  year={2012}
}
Water expulsion by the contractile vacuole (CV) in Dictyostelium is carried out by a giant kiss-and-run focal exocytic event during which the two membranes are only transiently connected but do not completely merge. We present a molecular dissection of the GTPase Rab8a and the exocyst complex in tethering of the contractile vacuole to the plasma membrane, fusion, and final detachment. Right before discharge, the contractile vacuole bladder sequentially recruits Drainin, a Rab11a effector, Rab8a… CONTINUE READING

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