Rab7 plays a B cell-intrinsic and critical role in T-dependent and T-independent antibody responses by mediating AID expression and class switch DNA recombination (IRM8P.706)

@inproceedings{Xu2014Rab7PA,
  title={Rab7 plays a B cell-intrinsic and critical role in T-dependent and T-independent antibody responses by mediating AID expression and class switch DNA recombination (IRM8P.706)},
  author={Zhenming Xu and Egest J. Pone and Tonika Lam and Aimee L Edinger and Paolo Casali},
  year={2014}
}
Rab7 is a small GTPase that mediates endosomal functions and regulates T cell homeostasis. Here, we have addressed the B cell-inherent role of Rab7 in antibody responses and underlying mechanisms by constructing Igh+/Cγ1-cre Rab7fl/fl mice. These mice displayed normal B cell and T cell development and survival, and were knocked-out of the Rab7 gene specifically in B cells activated to undergo IgH germline Iγ1-Sγ1-Cγ1 transcription. This transcription process is induced by IL-4 plus a primary… CONTINUE READING