Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking.

  title={Rab7 palmitoylation is required for efficient endosome-to-TGN trafficking.},
  author={Graziana Modica and Olga Skorobogata and Etienne Sauvageau and Adriano Vissa and Christopher M Yip and Peter Kijun Kim and Hugo Wurtele and Stephane Lefrancois},
  journal={Journal of cell science},
  volume={130 15},
Retromer is a multimeric protein complex that mediates endosome-to-trans-Golgi network (TGN) and endosome-to-plasma membrane trafficking of integral membrane proteins. Dysfunction of this complex has been linked to Alzheimer's disease and Parkinson's disease. The recruitment of retromer to endosomes is regulated by Rab7 (also known as RAB7A) to coordinate endosome-to-TGN trafficking of cargo receptor complexes. Rab7 is also required for the degradation of internalized integral membrane proteins… CONTINUE READING
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