Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases

@article{Lanzetti2004Rab5IA,
  title={Rab5 is a signalling GTPase involved in actin remodelling by receptor tyrosine kinases},
  author={Letizia Lanzetti and Andrea Palamidessi and Liliana Beatriz Areces and Giorgio Scita and Pier Paolo Di Fiore},
  journal={Nature},
  year={2004},
  volume={429},
  pages={309-314}
}
Rab5 is a small GTPase involved in the control of intracellular trafficking, both at the level of receptor endocytosis and endosomal dynamics. The finding that Rab5 can be activated by receptor tyrosine kinases (RTK) raised the question of whether it also participates in effector pathways emanating from these receptors. Here we show that Rab5 is indispensable for a form of RTK-induced actin remodelling, called circular ruffling. Three independent signals, originating from Rab5… CONTINUE READING
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