Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning.

@article{Tsetsenis2011Rab3BPI,
  title={Rab3B protein is required for long-term depression of hippocampal inhibitory synapses and for normal reversal learning.},
  author={Theodoros Tsetsenis and Thomas J. Younts and Chiayu Q. Chiu and Pascal S Kaeser and Pablo E Castillo and Thomas C S{\"u}dhof},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 34},
  pages={14300-5}
}
Rab3B, similar to other Rab3 isoforms, is a synaptic vesicle protein that interacts with the Rab3-interacting molecule (RIM) isoforms RIM1α and RIM2α as effector proteins in a GTP-dependent manner. Previous studies showed that at excitatory synapses, Rab3A and RIM1α are essential for presynaptically expressed long-term potentiation (LTP), whereas at inhibitory synapses RIM1α is required for endocannabinoid-dependent long-term depression (referred to as "i-LTD"). However, it remained unknown… CONTINUE READING