Rab3A and Rab3D control the total granule number and the fraction of granules docked at the plasma membrane in PC12 cells.

@article{Martelli2000Rab3AAR,
  title={Rab3A and Rab3D control the total granule number and the fraction of granules docked at the plasma membrane in PC12 cells.},
  author={Alberto Maria Martelli and Giovanna Tabellini and Darshan K Koticha and Renato Bareggi and Giulia Baldini},
  journal={Traffic},
  year={2000},
  volume={1 12},
  pages={976-86}
}
Rab proteins are Ras-like GTPases that regulate traffic along the secretory or endocytic pathways. Within the Rab family, Rab3 proteins are expressed at high levels in neurons and endocrine cells where they regulate release of dense core granules and synaptic vesicles. Immunoelectron microscopy shows that Rab3A and Rab3D can coexist on the same granule before and after docking. Using electron microscopy of transfected PC12 cells, we report that expression of wild-type Rab3A (or Rab3D) increases… CONTINUE READING