Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes

  title={Rab38 and Rab32 control post-Golgi trafficking of melanogenic enzymes},
  author={Christina Wasmeier and Maryse Romao and Lynn Plowright and Dorothy C Bennett and Graça Raposo and Miguel C. Seabra},
  journal={The Journal of Cell Biology},
  pages={271 - 281}
A mutation in the small GTPase Rab38 gives rise to the mouse coat color phenotype "chocolate" (cht), implicating Rab38 in the regulation of melanogenesis. However, its role remains poorly characterized. We report that cht Rab38(G19V) is inactive and that the nearly normal pigmentation in cht melanocytes results from functional compensation by the closely related Rab32. In cht cells treated with Rab32-specific small interfering RNA, a dramatic loss of pigmentation is observed. In addition to… CONTINUE READING
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