Rab35: GEFs, GAPs and effectors.

@article{Chaineau2013Rab35GG,
  title={Rab35: GEFs, GAPs and effectors.},
  author={Mathilde Chaineau and Maria S Ioannou and Peter S McPherson},
  journal={Traffic},
  year={2013},
  volume={14 11},
  pages={
          1109-17
        }
}
Rabs are the largest family of small GTPases and are master regulators of membrane trafficking. Following activation by guanine-nucleotide exchange factors (GEFs), each Rab binds a specific set of effector proteins that mediate the various downstream functions of that Rab. Then, with the help of GTPase-activating proteins, the Rab converts GTP to GDP, terminating its function. There are over 60 Rabs in humans and only a subset has been analyzed in any detail. Recently, Rab35 has emerged as a… CONTINUE READING

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