Rab27a: a new face in beta cell metabolism-secretion coupling.

  title={Rab27a: a new face in beta cell metabolism-secretion coupling.},
  author={Toru Aizawa and Mitsuhisa Komatsu},
  journal={The Journal of clinical investigation},
  volume={115 2},
In pancreatic beta cells, not only insulin exocytosis per se, but translocation of beta granules toward the plasma membrane--an event upstream of exocytosis--are under the control of glucose. However, the molecular basis of this translocation has been poorly understood. Rab27a-mediated translocation of glucose-induced beta granules is reported in this issue of the JCI. Rab27a or its effector molecule may constitute a novel pharmacological target because potentiation of the Rab27a pathway is… CONTINUE READING

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