Rab25 regulates integrin expression in polarized colonic epithelial cells

@inproceedings{Krishnan2013Rab25RI,
  title={Rab25 regulates integrin expression in polarized colonic epithelial cells},
  author={Moorthy Krishnan and Lynne A. Lapierre and Byron C. Knowles and James R Goldenring},
  booktitle={Molecular biology of the cell},
  year={2013}
}
Rab25 is a tumor suppressor for colon cancer in humans and mice. To identify elements of intestinal polarity regulated by Rab25, we developed Caco2-BBE cell lines stably expressing short hairpin RNA for Rab25 and lines rescuing Rab25 knockdown with reexpression of rabbit Rab25. Rab25 knockdown decreased α2-, α5-, and β1-integrin expression. We observed colocalization and direct association of Rab25 with α5β1-integrins. Rab25 knockdown also up-regulated claudin-1 expression, increased… CONTINUE READING
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