Rab22a regulates the recycling of membrane proteins internalized independently of clathrin.

@article{Weigert2004Rab22aRT,
  title={Rab22a regulates the recycling of membrane proteins internalized independently of clathrin.},
  author={Roberto Weigert and Albert Chi Yeung and Jean Li and Julie G Donaldson},
  journal={Molecular biology of the cell},
  year={2004},
  volume={15 8},
  pages={
          3758-70
        }
}
  • Roberto Weigert, Albert Chi Yeung, +1 author Julie G Donaldson
  • Published in Molecular biology of the cell 2004
  • Biology, Medicine
  • Plasma membrane proteins that are internalized independently of clathrin, such as major histocompatibility complex class I (MHCI), are internalized in vesicles that fuse with the early endosomes containing clathrin-derived cargo. From there, MHCI is either transported to the late endosome for degradation or is recycled back to the plasma membrane via tubular structures that lack clathrin-dependent recycling cargo, e.g., transferrin. Here, we show that the small GTPase Rab22a is associated with… CONTINUE READING

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