Rab1a regulates sorting of early endocytic vesicles.

  title={Rab1a regulates sorting of early endocytic vesicles.},
  author={Aparna Mukhopadhyay and Jose A Quiroz and Allan W. Wolkoff},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={306 5},
We previously reported that Rab1a is associated with asialoorosomucoid (ASOR)-containing early endocytic vesicles, where it is required for their microtubule-based motility. In Rab1a knockdown (KD) cell lines, ASOR failed to segregate from its receptor and, consequently, did not reach lysosomes for degradation, indicating a defect in early endosome sorting… CONTINUE READING