Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication.

@article{Tang2014Rab18FD,
  title={Rab18 facilitates dengue virus infection by targeting fatty acid synthase to sites of viral replication.},
  author={W Tang and Ren-Jye Lin and Ching-Len Liao and Yi-Ling Lin},
  journal={Journal of virology},
  year={2014},
  volume={88 12},
  pages={6793-804}
}
UNLABELLED Positive-sense RNA viruses, such as dengue virus (DENV), hijack the intracellular membrane machinery for their own replication. The Rab18 protein, a member of the Rab GTPase family, key regulators of membrane trafficking, is located on the organelles involved in DENV infection, such as the endoplasmic reticulum (ER) and lipid droplets (LDs). In this study, we addressed the potential involvement of Rab18 in DENV infection by using cells overexpressing the wild-type, GTP-bound active… CONTINUE READING

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