Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein.

  title={Rab11a and HSP90 regulate recycling of extracellular alpha-synuclein.},
  author={Jun Liu and Jian-peng Zhang and Min Shi and Thomas Quinn and Joshua M. Bradner and Richard P. Beyer and Shengdi Chen and Jing Zhang},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={29 5},
Growing evidence suggests that extracellular alpha-synuclein (eSNCA) may play an important role in the pathogenesis of Parkinson's disease (PD) and related synucleinopathies by producing neurotoxicity directly or via activation of glia. However, the mechanisms involved in the trafficking of eSNCA in neurons and/or glia remain unclear. Here, we demonstrated that eSNCA could be resecreted out of neurons via a process modulated by a recycling endosome regulator rab11a in addition to being degraded… CONTINUE READING


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