Rab11 regulates exocytosis of recycling vesicles at the plasma membrane.

  title={Rab11 regulates exocytosis of recycling vesicles at the plasma membrane.},
  author={Senye Takahashi and Keiji Kubo and Satoshi Waguri and Atsuko Yabashi and Hye-Won Shin and Yohei Katoh and Kazuhisa Nakayama},
  journal={Journal of cell science},
  volume={125 Pt 17},
Rab11 is known to associate primarily with perinuclear recycling endosomes and regulate recycling of endocytosed proteins. However, the recycling step in which Rab11 participates remains unknown. We show here that, in addition to causing tubulation of recycling endosomes, Rab11 depletion gives rise to accumulation of recycling carriers containing endocytosed transferrin and transferrin receptor beneath the plasma membrane. We also show that the carriers are transported from perinuclear… CONTINUE READING
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