Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour

  title={Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour},
  author={Carlo Breda and Marie L. Nugent and Jasper G. Estranero and Charalambos P Kyriacou and Tiago F Outeiro and Joern R Steinert and Flaviano Giorgini},
  booktitle={Human molecular genetics},
A central pathological hallmark of Parkinson's disease (PD) is the presence of proteinaceous depositions known as Lewy bodies, which consist largely of the protein α-synuclein (aSyn). Mutations, multiplications and polymorphisms in the gene encoding aSyn are associated with familial forms of PD and susceptibility to idiopathic PD. Alterations in aSyn impair neuronal vesicle formation/transport, and likely contribute to PD pathogenesis by neuronal dysfunction and degeneration. aSyn is… CONTINUE READING
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alpha-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent

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