Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein of Legionella pneumophila*S⃞

@article{Brombacher2009Rab1GN,
  title={Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major
 Phosphatidylinositol 4-Phosphate-binding Effector Protein of Legionella
 pneumophila*S⃞},
  author={Eva Brombacher and Simon Urwyler and Curdin Ragaz and Stefan S. Weber and Keiichiro Kami and Michael Overduin and Hubert Hilbi},
  journal={The Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={4846 - 4856}
}
The causative agent of Legionnaires disease, Legionella pneumophila, forms a replicative vacuole in phagocytes by means of the intracellular multiplication/defective organelle trafficking (Icm/Dot) type IV secretion system and translocated effector proteins, some of which subvert host GTP and phosphoinositide (PI) metabolism. The Icm/Dot substrate SidC anchors to the membrane of Legionella-containing vacuoles (LCVs) by specifically binding to phosphatidylinositol 4-phosphate (PtdIns(4)P). Using… CONTINUE READING
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