Rab proteins and the compartmentalization of the endosomal system.

@article{WandingerNess2014RabPA,
  title={Rab proteins and the compartmentalization of the endosomal system.},
  author={Angela Wandinger-Ness and Marino Zerial},
  journal={Cold Spring Harbor perspectives in biology},
  year={2014},
  volume={6 11},
  pages={a022616}
}
Of the approximately 70 human Rab GTPases, nearly three-quarters are involved in endocytic trafficking. Significant plasticity in endosomal membrane transport pathways is closely coupled to receptor signaling and Rab GTPase-regulated scaffolds. Here we review current literature pertaining to endocytic Rab GTPase localizations, functions, and coordination with regulatory proteins and effectors. The roles of Rab GTPases in (1) compartmentalization of the endocytic pathway into early, recycling… CONTINUE READING