Rab escort protein 1 (REP1) in intracellular traffic: a functional and pathophysiological overview.

@article{Preising2004RabEP,
  title={Rab escort protein 1 (REP1) in intracellular traffic: a functional and pathophysiological overview.},
  author={M N Preising and Carmen Ayuso},
  journal={Ophthalmic genetics},
  year={2004},
  volume={25 2},
  pages={101-10}
}
The intracellular distribution of proteins, compartments, substrates, and products is an active process called intracellular traffic. Control of intracellular traffic is established by small GTP-binding proteins (Rab proteins). Rab proteins are modified by geranyl-geranyl moieties necessary for membrane association and target-protein recognition. Geranyl-geranyl groups are transferred to Rab proteins by geranyl-geranyl transferase 2 (GGTase2). GGTase2 requires Rab escort protein 1 (REP1) to… CONTINUE READING