RYR1 and RYR3 have different roles in the assembly of calcium release units of skeletal muscle.

@article{Protasi2000RYR1AR,
  title={RYR1 and RYR3 have different roles in the assembly of calcium release units of skeletal muscle.},
  author={Feliciano Protasi and Hiroaki Takekura and Yue Wang and Syue Rong Chen and Gerhard Meissner and Paul D. Allen and Clara Franzini-armstrong},
  journal={Biophysical journal},
  year={2000},
  volume={79 5},
  pages={2494-508}
}
Calcium release units (CRUs) are junctions between the sarcoplasmic reticulum (SR) and exterior membranes that mediates excitation contraction (e-c) coupling in muscle cells. In skeletal muscle CRUs contain two isoforms of the sarcoplasmic reticulum Ca(2+)release channel: ryanodine receptors type 1 and type 3 (RyR1 and RyR3). 1B5s are a mouse skeletal muscle cell line that carries a null mutation for RyR1 and does not express either RyR1 or RyR3. These cells develop dyspedic SR/exterior… CONTINUE READING
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