RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes

@inproceedings{Rose2016RYBPSP,
  title={RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes},
  author={Nathan Rose and Hamish W King and Neil P. Blackledge and Nadezda A Fursova and Katherine Ji Ember and Roman Fischer and Benedikt M. Kessler and Robert J Klose},
  booktitle={eLife},
  year={2016}
}
Polycomb group (PcG) proteins function as chromatin-based transcriptional repressors that are essential for normal gene regulation during development. However, how these systems function to achieve transcriptional regulation remains very poorly understood. Here, we discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex 1 (PRC1) is defined by the composition of its catalytic subunits and is highly regulated by RYBP/YAF2-dependent stimulation. In mouse… CONTINUE READING
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