RX-207, a Small Molecule Inhibitor of Protein Interaction with Glycosaminoglycans (SMIGs), Reduces Experimentally Induced Inflammation and Increases Survival Rate in Cecal Ligation and Puncture (CLP)-Induced Sepsis

@article{Juhs2017RX207AS,
  title={RX-207, a Small Molecule Inhibitor of Protein Interaction with Glycosaminoglycans (SMIGs), Reduces Experimentally Induced Inflammation and Increases Survival Rate in Cecal Ligation and Puncture (CLP)-Induced Sepsis},
  author={{\vS}tefan Juh{\'a}s and Nicholas Harris and Gabriela Il’kov{\'a} and Pavol Reh{\'a}k and Ferenc Zsila and Faina Yurgenzon Kogan and Orly Lahmy and Regina Zhuk and Paul Gregor and Juraj Koppel},
  journal={Inflammation},
  year={2017},
  volume={41},
  pages={307-314}
}
The fused quinazolinone derivative, RX-207, is chemically and functionally related to small molecule inhibitors of protein binding to glycosaminoglycans (SMIGs). Composed of a planar aromatic amine scaffold, it inhibits protein binding to glycosaminoglycans (GAGs). RX-207 reduced neutrophil migration in thioglycollate-induced peritonitis (37%), inhibited carrageenan-induced paw edema (32%) and cerulein-induced pancreatitis (28%), and increased animal survival in the mouse model of cecal… CONTINUE READING
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