RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.

@article{Wadsworth1999RWJ6A,
  title={RWJ 67657, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.},
  author={Scott A. Wadsworth and Druie E. Cavender and Stephen A Beers and Praful Lalan and Peter H. Schafer and E A Malloy and Wenju Wu and Bohumila Fahmy and Gilbert C Olini and Joanne E. Davis and J L Pellegrino-Gensey and Michael P Wachter and John J. Siekierka},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={291 2},
  pages={680-7}
}
Tumor necrosis factor-alpha (TNF-alpha), a cytokine secreted by activated monocytes/macrophages and T lymphocytes, has been implicated in several disease states, including rheumatoid arthritis, inflammatory bowel disease, septic shock, and osteoporosis. Monocyte/macrophage production of TNF-alpha is dependent on the mitogen-activated protein kinase p38. RWJ… CONTINUE READING