RWD Domain as an E2 (Ubc9)-Interaction Module.

Abstract

An RWD domain is a well conserved domain found through bioinformatic analysis of the human proteome sequence; however, its function has been unknown. Ubiquitin-like modifications require the catalysis of three enzymes generally known as E1, E2, and E3. We solved the crystal structure of the E2 for the small ubiquitin-like modifiers (SUMO) in complex with an… (More)
DOI: 10.1074/jbc.M115.644047

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